Gastrointestinal conditions affecting drug absorption Case study Essay

Gastrointestinal conditions affecting drug absorption Case study

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Gastrointestinal conditions affecting drug absorption Case study

Lavinia Adjei is 50 years old. She has suffered from hypertension and type 2 diabetes for the past four years. For these long-term conditions, she takes aspirin 75mg daily, enalapril 20mg daily, simvastatin 20mg every night and

 

metformin 500mg three times a day. She was also diagnosed with Crohn’s disease when she was 20 years old. This illness is usually well managed by diet alone and she has been in remission for the last 10 years. Investigations

at that time confirmed distal iliac disease. Lavinia goes to the gym on a regular basis, does not drink alcohol but does smoke about between 5 and 10 cigarettes per day, depending on her level of anxiety.

Due to her recent promotion to a senior position in her company and the increased level of stress, her smoking has increased. She has also suffered a relapse of her Crohn’s, with an average of 10 bowel movements each day,

 

persistent bloody diarrhoea, abdominal cramps and weight loss. She also noticed that when she carried out her usual home monitoring of her blood pressure and diabetes, both were out of control. On examination by her GP,

Lavinia was anxious, pale with slight tenderness in her right iliac fossa. Rectal examination revealed no abnormalities. The GP discussed the use of prednisolone to manage Lavinia’s clinical symptoms but she explained that

during the last flare-up of her condition 10 years ago, she was unable to tolerate them as she constantly felt agitated and restless and her blood pressure and diabetes were not well controlled. In the light of her intolerance of conventional steroids, the GP prescribed another drug.

Gastrointestinal conditions affecting drug absorption Case study

RUBRIC
Excellent Quality 95-100%	Introduction 45-41 points The background and significance of the problem and a clear statement of the research purpose is provided. The search history is mentioned.		Literature Support 91-84  points The background and significance of the problem and a clear statement of the research purpose is provided. The search history is mentioned.			Methodology 58-53 points Content is well-organized with headings for each slide and bulleted lists to group related material as needed. Use of font, color, graphics, effects, etc. to enhance readability and presentation content is excellent. Length requirements of 10 slides/pages or less is met.
Average Score 50-85%	40-38 points More depth/detail for the background and significance is needed, or the research detail is not clear. No search history information is provided.		83-76  points Review of relevant theoretical literature is evident, but there is little integration of studies into concepts related to problem. Review is partially focused and organized. Supporting and opposing research are included. Summary of information presented is included. Conclusion may not contain a biblical integration.			52-49  points Content is somewhat organized, but no structure is apparent. The use of font, color, graphics, effects, etc. is occasionally detracting to the presentation content. Length requirements may not be met.
Poor Quality 0-45%	37-1 points The background and/or significance are missing. No search history information is provided.		75-1 points Review of relevant theoretical literature is evident, but there is no integration of studies into concepts related to problem. Review is partially focused and organized. Supporting and opposing research are not included in the summary of information presented. Conclusion does not contain a biblical integration.			48-1 points There is no clear or logical organizational structure. No logical sequence is apparent. The use of font, color, graphics, effects etc. is often detracting to the presentation content. Length requirements may not be met
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