Red Blood Cells Count Questions
Order ID: 89JHGSJE83839 Style: APA/MLA/Harvard/Chicago Pages: 5-10 Instructions:
Part 1:
Suppose that vampires actually exist and that the condition is caused by a prion disease that eliminates the ability to manufacture red blood cells (RBC) by changing their bodys DNA throughout the bone marrow. They need to drink blood in order to replenish their RBC count. RBC are normally produced in the bone marrow and destroyed in the spleen once they have existed for about 4 months. Sketch a diagram of the two regulatory pathways, including feedback loops, described here (i.e. sketch one diagram for normal humans and sketch another for the modified vampire pathway): The number of red blood cells (RBC count) in the body is the variable being regulated. Over time, the number of RBC decreases due to the action of the spleen. However, if exposed to sunlight, which triggers activation of Vitamin D, which in vampires dramatically raises the Ca++ concentration in plasma, triggering apoptosis (cell death) of RBC so sunlight is a stimulus that will decrease RBC. The kidneys have nerve endings that detect blood O2 levels as a measure of RBC count and release the hormone erythropoietin (EPO) to stimulate release of RBC from the bone marrow. However, in vampires the bone marrow cannot make more cells. They have evolved a mechanism where the release of EPO triggers a diversion of blood flow away from the spleen to slow the rate of RBC destruction. Also, detection of low RBC count triggers the vampire brain to release the hormone vampyrine which causes the sensation of hunger. If the vampire feeds, levels of RBC go up since they are not digested but transported into the blood vessels. (6 points)
Part 2:
Read the paper Prediabetes Phenotype Influences Improvements in Glucose Homeostasis with Resistance Training by JD Eikenberg et. al (2016) from PLOS One posted as a .pdf file in the Introduction to Physiology Canvas folder (or found here https://doi.org/10.1371/journal.pone.0148009 ) (Links to an external site.)and answer the questions about it. There are 8 questions worth 1-3 points each.
Write your answers in complete sentences. I am expecting your answers to be from one to five sentences, depending on the question. (I am not looking for a lot of writing, just to see if you read and understood the paper and to see what your opinion is about some of the issues raised in it.) I will award points based on the correctness and completeness of answers, or if it is your opinion that it makes sense and that you explained your position clearly.
RUBRIC
Excellent Quality
95-100%
Introduction 45-41 points
The background and significance of the problem and a clear statement of the research purpose is provided. The search history is mentioned.
Literature Support
91-84 points
The background and significance of the problem and a clear statement of the research purpose is provided. The search history is mentioned.
Methodology
58-53 points
Content is well-organized with headings for each slide and bulleted lists to group related material as needed. Use of font, color, graphics, effects, etc. to enhance readability and presentation content is excellent. Length requirements of 10 slides/pages or less is met.
Average Score
50-85%
40-38 points
More depth/detail for the background and significance is needed, or the research detail is not clear. No search history information is provided.
83-76 points
Review of relevant theoretical literature is evident, but there is little integration of studies into concepts related to problem. Review is partially focused and organized. Supporting and opposing research are included. Summary of information presented is included. Conclusion may not contain a biblical integration.
52-49 points
Content is somewhat organized, but no structure is apparent. The use of font, color, graphics, effects, etc. is occasionally detracting to the presentation content. Length requirements may not be met.
Poor Quality
0-45%
37-1 points
The background and/or significance are missing. No search history information is provided.
75-1 points
Review of relevant theoretical literature is evident, but there is no integration of studies into concepts related to problem. Review is partially focused and organized. Supporting and opposing research are not included in the summary of information presented. Conclusion does not contain a biblical integration.
48-1 points
There is no clear or logical organizational structure. No logical sequence is apparent. The use of font, color, graphics, effects etc. is often detracting to the presentation content. Length requirements may not be met
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Red Blood Cells Count Questions