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Lysosomal Hydrolases Cell Biology Essay Discussion
The M6P-receptor would (fail in/ succeed in) releasing its associated cargo and these proteins would be recycled back to the (Smooth ER/Trans-Golgi-compartment/rough ER). As a result, (“proteosomal”/ “endosomal”/ “lysosomal) proteins would fail to be delivered to the (“endosomal/lysosomal/ proteosomal)compartment and would accumulate in the (“TGN/Nucleus/Smooth ER.)
Cargo proteins containing the M6P (“communication signal”/”termination signal”/ “sorting signal”) would (succeed/fail) in binding efficiently to the M6Preceptor protein. The result in this case would be that lysosomal (“kinases”/”oxidoreductases”/”isomerases”/”hydrolases) would be secreted by the default pathway.
The mutated (“tyrosine”, “phenylalanine) esidue was probably a part of the YXX_ (where X is anything and _ is a [bulky hydrophobic] amino acid) in the (termination”, “cytosolic”, “vesicular”) domain of the LDL-R. This sequence interacts with the _2 subunit of the (“GGA1″, “AP181”, “AP2“) assembly particle and is responsible for clathrin-mediated internalization of the LDL-R bound to LDL.
3.In polarized MDCK cells, proteins X and Y normally are located to the apical plasma membrane domain, and are not observed to any significant degree in the basolateral membranes of these cells. To investigate the manner in which these two proteins arrive at this subcellular localization you transform these cells with a plasmid containing a dominant-negative form of one of the proteins of the AP-2 adaptor protein complex and observe the subsequent distribution of proteins X and Y. After treatment, protein X remains at the apical membrane, but protein Y now is primarily observed in the basolateral membranes. Explain how expression of a dominant-negative AP-2 complex can affect the subcellular distribution of protein Y but not protein X?
Lysosomal Hydrolases Cell Biology Essay Discussion
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Excellent Quality 95-100%
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Introduction
45-41 points The background and significance of the problem and a clear statement of the research purpose is provided. The search history is mentioned. |
Literature Support 91-84 points The background and significance of the problem and a clear statement of the research purpose is provided. The search history is mentioned. |
Methodology 58-53 points Content is well-organized with headings for each slide and bulleted lists to group related material as needed. Use of font, color, graphics, effects, etc. to enhance readability and presentation content is excellent. Length requirements of 10 slides/pages or less is met. |
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Average Score 50-85% |
40-38 points More depth/detail for the background and significance is needed, or the research detail is not clear. No search history information is provided. |
83-76 points Review of relevant theoretical literature is evident, but there is little integration of studies into concepts related to problem. Review is partially focused and organized. Supporting and opposing research are included. Summary of information presented is included. Conclusion may not contain a biblical integration. |
52-49 points Content is somewhat organized, but no structure is apparent. The use of font, color, graphics, effects, etc. is occasionally detracting to the presentation content. Length requirements may not be met. |
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Poor Quality 0-45% |
37-1 points The background and/or significance are missing. No search history information is provided. |
75-1 points Review of relevant theoretical literature is evident, but there is no integration of studies into concepts related to problem. Review is partially focused and organized. Supporting and opposing research are not included in the summary of information presented. Conclusion does not contain a biblical integration. |
48-1 points There is no clear or logical organizational structure. No logical sequence is apparent. The use of font, color, graphics, effects etc. is often detracting to the presentation content. Length requirements may not be met |
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