UC Davis Chemical Formulas and the Ratio Indication
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UC Davis Chemical Formulas and the Ratio Indication
You must answer using a Word file document (.doc or .docx) or .txt file. Please DO NOT attach images (drawings or handwritten math) within the file.
Questions:
2. You have a solution of 1 M acetic acid. The chemical formula of acetic acid is CH3COOH. When the proton dissociates from acetic acid, you are left with CH3COO-. The pKa of acetic acid is 4.75.
(A) Please show your math to indicate the ratio of CH3COO- to CH3COOH at a pH of 3.75. (2 pts)
(B) Please show your math to indicate the ratio of CH3COO- to CH3COOH at a pH of 4.75. (2 pts)
(C) Please show your math to indicate the ratio of CH3COO- to CH3COOH at a pH of 6.75. (2 pts)
(D) At which pH would acetic acid have its most optimal buffering capability? (2 pts)
3. Carnosine is a dipeptide found in the cytoplasm of muscle cells. It is also known as ?-Alanyl-L-histidine. It has a pKa of 6.83. At rest, muscle pH = 7.1. After strenuous exercise, muscle pH can reach as low as 6.4 from glycolysis, the generation of lactate and H+ ion.
(A) Using Henderson-Hasselbalch and showing your math, please determine the percentage of protonated carnosine (relative to total carnosine) in muscle at rest. (4 pts)
(B) Using Henderson-Hasselbalch and showing your math, please determine the percentage of protonated carnosine (relative to total carnosine) in muscle after strenuous exercise. (4 pts)
(C) After finding your answers in parts 3A and 3B, in 50 words or less, what do you think is the role of carnosine in muscle cells? When answering, please consider the role of weak acids in biology. (3 pts)
4. When describing a blood buffering scenario, the terms “metabolic” and “respiratory” are used to describe an acidosis or alkalosis. In 100 words or less, how does one distinguish between when to use either term (“metabolic” or “respiratory”) when describing the blood buffering scenario being described? (5 pts)
5. Consider the following tri-peptide: Phe-Ala-Glu . Please describe the tripeptide in a paragraph that identifies its N-terminal amino acid, C-terminal amino acid, which is/are essential amino acid(s), the general characterization of the amino side chains (R groups), and the pI of the tripeptide. (6 pts)
RUBRIC
Excellent Quality
95-100%
Introduction 45-41 points
The background and significance of the problem and a clear statement of the research purpose is provided. The search history is mentioned.
Literature Support
91-84 points
The background and significance of the problem and a clear statement of the research purpose is provided. The search history is mentioned.
Methodology
58-53 points
Content is well-organized with headings for each slide and bulleted lists to group related material as needed. Use of font, color, graphics, effects, etc. to enhance readability and presentation content is excellent. Length requirements of 10 slides/pages or less is met.
Average Score
50-85%
40-38 points
More depth/detail for the background and significance is needed, or the research detail is not clear. No search history information is provided.
83-76 points
Review of relevant theoretical literature is evident, but there is little integration of studies into concepts related to problem. Review is partially focused and organized. Supporting and opposing research are included. Summary of information presented is included. Conclusion may not contain a biblical integration.
52-49 points
Content is somewhat organized, but no structure is apparent. The use of font, color, graphics, effects, etc. is occasionally detracting to the presentation content. Length requirements may not be met.
Poor Quality
0-45%
37-1 points
The background and/or significance are missing. No search history information is provided.
75-1 points
Review of relevant theoretical literature is evident, but there is no integration of studies into concepts related to problem. Review is partially focused and organized. Supporting and opposing research are not included in the summary of information presented. Conclusion does not contain a biblical integration.
48-1 points
There is no clear or logical organizational structure. No logical sequence is apparent. The use of font, color, graphics, effects etc. is often detracting to the presentation content. Length requirements may not be met
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UC Davis Chemical Formulas and the Ratio Indication